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Doctor's Data

Zonulin Family Protein (Properdin), stool-Doctor's Data Kit

Zonulin Family Protein (Properdin), stool-Doctor's Data Kit

Regular price $145.00 USD
Regular price Sale price $145.00 USD
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Note: This is a home collection test kit that will be mailed to you.

Fasting Required:
Doctor's Data
Average processing time 7-10 business days
Note: Result turnaround times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Special Instructions:
If you are taking antifungal or antibiotic medications, please finish the course of medication, and then wait three days before starting this collection. Please refrain from taking digestive enzymes, antacids, and aspirin for two days prior to and during the specimen collection, unless otherwise instructed by your physician. Refrain from taking probiotic supplements for two weeks prior to specimen collection unless instructed otherwise by your physician.
The level of the zonulin antigen in stool may provide a noninvasive indication of intestinal permeability (“leaky gut”). Research to date has identified zonulin as the only physiologically reversible regulator of permeability of the GI endothelial cell barrier. Numerous studies have shown that a chronically high release of zonulin from the GI epithelial cells is associated with Celiac disease, non-celiac gluten sensitivity (NCGS), Diabetes, chronic hyperglycemia, cigarette smoking and other GI and systemic autoimmune and pro-inflammatory conditions. In a healthy GI tract, the tight junction protein complexes between endothelial cells prevent unregulated influx of luminal contents. However, specific triggers, such as gliadin for people with celiac disease or NCGS, can lead to high levels of zonulin in the GI tract. This can induce the breakdown of the tight junctions, leading to excessive paracellular influx of pro-inflammatory and highly antigenic macromolecules. As a result, an elevated level of the zonulin antigen in stool is a clinically useful biomarker of intestinal permeability. What's more, it can be valuable for monitoring therapeutic interventions as well. Fecal zonulin can be ordered as a stand-alone test or as an add-on to a Comprehensive Stool Analysis.
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